Quinine and a Resistance Factor

Artemether saved a patient with severe falciparum malaria after quinine treatment failure (R III type of quinine resistance).

Quinine has been one of the most effective drugs for the treatment of malaria since its introduction into clinical use several centuries ago. It is the drug of choice in severe falciparum malaria. Although the efficacy of the drug has gradually declined against malaria strains in various parts of Southeast Asia, resistance has not yet become a worldwide problem. Treatment failures from quinine ...

Quinine Bihydrochloride v. Quinine Bisulphate

come across a medical man who avers that it is a useless salt of Quinine and that the only salt of anv use for injection is the Bisulpliate of Quinine, Now, from what I can remember of the Physiology of the Blood, I should have thought that the Bisulpliate was a much more foreign salt to the plasma than the Bihydrochloride. As far as I can remember the plasma contains Chlorides in abundance, bu...

Malaria and Quinine Resistance: A Medical and Scientific Issue between Brazil and Germany (1907–19)

This article addresses the discussion about quinine-resistant malaria plasmodium in the early decades of the twentieth century. Observed by Arthur Neiva in Rio de Janeiro in 1907, the biological and social resistance of malaria sufferers to preventive and curative treatment with quinine was corroborated three years later by Oswaldo Cruz during the construction of the Madeira-Mamoré Railway in t...

Quinine and Malaria

To the Editor o) "The inuiah ivibdjoal Gazette." Sir,?Lieut. H. Stott has. in t\vo letters published in your paper, brought up the subject of /-(lay fever " and the value of quinine injection as contrasted with its oral administration in Malaria. , . ? . This induces.roe to forward to you a few records which may b? of interest to him and other leadeis of the Gazette. The first are samples of a ...

Sulphonamides and Quinine